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It focuses on the SURPASS and SURMOUNT clinical trial programs, presently the best evaluations of Tirzepatide's clinical efficacy

The cortisol response tracks roughly proportionally with GH pulse amplitude bigger GH pulse, bigger cortisol co-secretion

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Preclinical studies indicate potential roles in: Supporting healthy fat metabolism and reduction of adipogenesis Improving insulin sensitivity in metabolic research models Enhancing NAD+ salvage pathway efficiency Exploring effects on energy homeostasis and longevity pathways These findings remain preliminary and confined to laboratory and animal models

Ann Neurol 1994;36:680-1

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