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Table of Contents How Retatrutide May Affect Blood Pressure Evidence From Clinical Trials on Cardiovascular Outcomes Who Should Exercise Caution With This Treatment Monitoring Blood Pressure During Retatrutide Therapy Interactions With Antihypertensive Medicines Current MHRA and NICE Guidance on Use in the UK Scientific References Frequently Asked Questions How Retatrutide May Affect Blood Pressure Retatrutide has been associated with modest blood pressure reductions in Phase 2 trials, most likely driven by weight loss-mediated decreases in vascular resistance, with additional contributions from possible natriuretic and endothelial effects extrapolated from the GLP-1 drug class