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Nrf2 depletion in macrophages leads to increased foam cell formation, increases the M1 inflammatory phenotype with enhanced expression of pro-inflammatory monocyte chemoattractant protein-1 and interleukin-6, and aggravates atherosclerosis (244, 245)
Exenatide LAR exhibited durable glucose-lowering efficacy, with stable glucose improvements and reductions in cardiometabolic risk factors for up to 3 years, and a tolerable safety profile [70]
Case report: amelioration of severe metabolic dysfunction-associated steatohepatitis after switching from conventional GLP-1RAs to tirzepatide
Gastrointestinal issues, such as diarrhea, nausea and constipation, are perhaps the most widely reported side effects (research has found that these impact up to 60% of users)
10.3389/fphar.2014.00151 6
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