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3) Some believe these drugs will not see widespread adoption because they are most effective subcutaneously (administered via an autoinjector as pictured here): While a certain subset will always have a phobia of needles, its worth considering the lengths that people have gone to in the past to lose weight (taking pills with tapeworms in them, for example)

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This argument-based approach should be implemented as a standard approach to validity for PROMs

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doi: 10.1016/j.mayocp.2015.02.001