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arthralgia incidence in trials is generally similar to placebo Rapid weight loss from GLP-1 treatment may alter biomechanical loading on joints, causing temporary adjustment-related discomfort Patients prescribed GLP-1 medications often have type 2 diabetes or obesity, conditions independently associated with increased osteoarthritis rates Seek medical advice for severe, worsening, or persistent joint pain, or if accompanied by swelling, redness, warmth, or systemic symptoms Report suspected medication side effects through the MHRA Yellow Card scheme to support ongoing safety monitoring Table of Contents Understanding GLP-1 Medications and Their Common Side Effects GLP-1 receptor agonists, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda), most commonly cause gastrointestinal side effects such as nausea, vomiting, and diarrhoea

In such cases, no treatment is generally required If required, a surgical excision and complete removal of the macule, primarily to address cosmetic issues may be undertaken Treatment of the underlying associated genetic disorder, if any Follow-up care with regular screening and check-ups are encouraged How can Melanotic Macules of Oral Mucosa be Prevented

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Semaglutide is found in other popular weight loss medications, including Ozempic, but Wegovy contains higher doses

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The FDA and other regulatory agencies have conducted extensive reviews of safety data from clinical trials and post-marketing surveillance