In addition, TMAO induces several inflammatory pathways, which cause the activation of pro-inflammatory cytokines such as IL-6 and TNF- which causes chronic inflammation thereby causing plaque formation and plaque rupture leading to cardiovascular disease [71]
Overall the absolute risk was around 40% when a GLP1-RA was specifically used to lose weight compared to around 27% when the drug was used for type II diabetes
While GLP-1 and GIP mainly help regulate appetite, insulin, and fullness, glucagon may help increase energy expenditure and fat metabolism
38 The Pharmaceutical Benefits Advisory Committee has recently recommended semaglutide 2.4 mg be listed on the PBS for adults with established cardiovascular disease and BMI 35 kg/m 2 or higher, or 32.5 kg/m 2 or higher for Asian, Aboriginal or Torres Strait Islander populations
Solution: Reduce volume, not frequency
By understanding how these signaling molecules work together, you can optimize their usage for maximum benefits