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The weight-loss equivalency framework (what the trials show) The table below compares mean weight loss at week 72 from the phase 3 obesity trials
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Putative mechanisms of tirzepatide-mediated nephroprotection The pathogenesis of CKD in patients with T2D likely involves other potential contributors besides hyperglycemia, such as hypertension, dyslipidemia, obesity, insulin resistance, glomerular atherosclerosis, renal ischemia, and nephron aging [53]
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