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We chose SGLT-2 inhibitors as the secondary comparator because they are also used at a disease stage similar to GLP-1 receptor agonists and have not been associated with the outcome.16 For both cohorts, we defined cohort entry as the date of the first prescription for either a GLP-1 receptor agonist or the comparator drug during the study period

The assay based on the reaction of GSH with 5,5-dithio-bis-2-nitrobenzoic acid (DTNB) in the presence of glutathione reductase, was performed according to the protocol 56 and measured with a TECAN plate reader at 412 nm

10.1016/j.pbb.2017.07.014 66 ThomsenM.HolstJ

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Available from: Gomez-Amores L, Mate A, Miguel-Carrosco J, Jimenez L, Jos A, Camean AM, Revilla E, Santa-Maria C, Vasquez C

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