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In addition, the dual InsR/IGF-IR inhibitor linsitinib can prevent the emergence of breast cancer cells that are resistant to long-term estrogen deprivation or antiestrogen treatment and inhibit growth of established ER+ breast cancer xenografts in ovariectomized mice [107]

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Resolving the relative contributions of these mechanisms in vivo remains an important challenge for the field and will likely require quantitative imaging approaches capable of linking molecular events to tissue-scale dynamics

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