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Hyperglycemia drives the accumulation of advanced glycation end products AGEs, which activate the RAGE/MAPK signaling axis, thereby inhibiting Col-II synthesis and promoting a catabolic state in chondrocytes (31)
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That's the window where lipotropic support becomes clinically useful
Nevertheless, none of these studies looked at overall systematic side effects with the concern for general immunosuppression and negative CV side effects observed with many common immunosuppressants (264)
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Cava E, Yeat NC, Mittendorfer B
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