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FIGURE 1 3.3 Adjusted group comparisons ANCOVA analyses controlling for age and days since the start of psychiatric treatment revealed significant effects of prescription type for all four side effects: insomnia ( F 3, 642 = 3.24, p = 0.022), poor appetite ( F 3, 644 = 3.44, p = 0.017), end-of-dose crash ( F 3, 589 = 3.36, p = 0.019), and return of symptoms ( F 3, 595 = 2.97, p = 0.032)

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BPC 157 application largely counteracted changes at the microscopic level, including the formation of vacuoles and the loss of axons in the white matter, the formation of edema and the loss of motoneurons in the gray matter, and a decreased number of large myelinated axons in the rat caudal nerve from day 7