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These observations are consistent with the activity data of SULT2B1b allozymes toward pregnenolone previously reported 16 , suggesting that single nucleotide polymorphisms on the common region of the SULT2B1 gene may have a similar effect on the sulfating activity of the two splice variants of SULT2B1 toward pregnenolone

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The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin