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TB-500 has been shown to promote cell migration, angiogenesis, cytoskeletal reorganization, and anti-inflammatory signaling in preclinical models 1,2

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Ex-4 can significantly rescue memory deficits and neuropathological changes in APP/PS1 AD mice, and it can downregulate the activities of N -acetylglucosaminyltransferase III and bisecting N -acetyl-d-glucosamine through the Akt/GSK-3/-catenin signaling pathway [70]

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Primer sequences are shown in Supplementary Table S2

Nutraceuticals Nutraceuticals are foods containing health-bolstering effects so significant that they are seen to have medicinal benefit