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Ott C, Raff U, Schmidt S, et al

A larger follow-up RCT (n=72 older adults) confirmed these findings, additionally demonstrating improvements in gait speed (+0.14 m/s), grip strength, 6-minute walk distance, waist circumference reduction, and systolic blood pressure reduction (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]

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Internal metabolic improvement begins before external changes become obvious

Consistently, in a rat model of MIinduced heart failure, exendin-4 decreased susceptibility to atrial arrhythmogenesis, improved conduction properties, and attenuated atrial fibrosis [33]

Not directly, but they can lower a specific type of estrogen indirectly as a side effect of fat loss