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2628 In these mice, increased GLUT2 expression promotes glucose translocation into hepatocytes, indirectly increasing precursors for lipid synthesis and promoting hepatic steatosis

Average weight loss was ~2 kg (a bit less than liraglutide or semaglutide, but more than albiglutide)

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IGF-1 DES is a truncated synthetic analogue of IGF-1 lacking the N-terminal Gly-Pro-Glu tripeptide

Electrophysiology Brain slices were prepared from adult Glp1r-cre::tdTomato or Pomc-hrGFP male mice (aged 618 weeks) as previously described 49,50,51