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Tonic inhibition An inhibitory signal that is thought to utilize extrasynaptic receptors (not directly apposed to presynaptic release sites), may be decoupled from presynaptic spiking and occurs over long (minutes or more) periods

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Mol Ther Nucleic Acids (2020) 19:46881

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Standard treatment approaches include rest, ice, anti-inflammatory medications, physical therapy, bracing, and in some cases cortisone injections

this equates to roughly 3.4 million people