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In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26

A lot of early tests were conducted on rats, mice, chickens, and other animals, revealing potential benefits across different organs [3]

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Direct Dosage: A single B12 injection often delivers a much higher dose directly into the system than a typical daily oral tablet, particularly when considering the limited absorption rate of the latter, contributing to their perceived and actual strength. However, for individuals with mild dietary deficiencies and no underlying absorption problems, high-dose oral B12 supplements (e.g., 1000-2000mcg daily) can sometimes overcome the need for intrinsic factor by allowing for a small amount of passive absorption, eventually raising levels, though this method is less predictable and slower than direct injection

This represents a meaningful quality-of-life improvement even though the underlying structural issue persists

It's thought to work by promoting the formation of new blood vessels (angiogenesis), which improves blood flow and facilitates quicker healing