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However, its heterogeneous nature results in variable outcomes [67], prompting researchers to focus on active strategies for nanomedicine-mediated tumor targeting as alternative approaches to passive mechanisms, particularly in tumors with poor EPR effect, by leveraging molecular recognition, receptor-mediated transport, or engineered responsiveness for enhanced selectivity and intracellular uptake [68, 69]

Works best for small, stable areas

Regulatory T cells in the treatment of disease

Beyer W, Imlay J, Fridovich I

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