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The most clinically significant interaction concern involves antidiabetic medicines
One possible way to minimize the side-effects of the single drugs is to combine them to achieve synergistic effects, as reported recently with a combination of a DPP-IV inhibition, SSTR5 antagonism and GPR40 and TGR5 agonism, capable to raise circulatory active GLP-1(7-36) NH2 levels to more than 300-400 pM in mice (240)
If your testosterone therapy is genuinely needed, lifestyle changes alone will produce frustratingly little progress
That is 2.5 to 3 hours per week, a modest investment that can reduce muscle loss by 50-95%
A healthier microbiome supports GLP-1 activity and improves insulin sensitivity
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