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In fact, therapeutic doses of metformin (150 M) protect endothelial function by interacting with the orphan nuclear receptor Nur77/NR4A1 to reduce hyperglycaemic-induced ROS [113]

Glutathione is involved in regulating the genes and the production of cytokines that cause chronic inflammation

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Elevated brain glutamine levels in adults with autism spectrum disorder: A 7T MRS study

The availability of substrates and especially FAs to mitochondria serves as a limiting factor for mitochondrial function in energy production 15,16

Desensitization of insulin secretion