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PlexusDx's microdose GLP-1 protocol, available at $129/mo, offers an alternative approach for those seeking slower titration to reduce acute GI disruption while still achieving therapeutic benefit
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Most participants tolerated the medication well, with the most common side effects being mild to moderate digestive issues such as nausea, vomiting, or diarrheaparticularly when first starting the medication or increasing the dosage
A mild rise in resting heart rate is expected
More striking is the responder analysis: 63% of retatrutide participants in the 12 mg arm achieved 20% or greater weight loss at 48 weeks
Examples of such fusions are Ang2 blocking peptides fused to the anti-TNF adalimumab 27 or the anti-ErbB2 trastuzumab antibodies 28 as well as an IL-17A neutralising peptide fused to an anti-IL-22 antagonistic antibody 29
