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An intensive discussion on the pancreatic safety of incretin-based therapies initiated by publications of a single group have led to a thorough evaluation of non-clinical and clinical data by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) (3845)

Notably, the STEP trials demonstrated significant weight reductions in obese participants, forming a robust foundation for semaglutide's approval for weight management (Garvey et al., 2022)

doi:10.1056/NEJMoa2307563 2024 The Author(s)

The FDA's reasoning comes down to one word: need

This needle-free method is a major step forward in convenience, offering a more efficient way to reach your health goals

Instead the Fab 3F52/ECD structure is compatible with a tilted conformation of the ECD, where Fab 3F52 occupies partially the orthosteric binding site of the GLP-1R TM domain explaining the competitive effect of Fab 3F52 on BMS21-induced activation of GLP-1R (Fig