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Semaglutide: Mimicking a Natural Hormone Semaglutide mimics the GLP-1 hormone, which naturally occurs in the body and plays a role in reducing appetite

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Journal of Applied Physiology , 2019 Collagen and Fibroblast Modulation: It upregulates fibroblast activity, supporting tendon and ligament remodeling which makes it especially useful for athletes and post-op patients
Orforglipron shows typical GLP-1-related gastrointestinal effects and discontinuation due to gastrointestinal symptoms appears similar compared to oral semaglutide