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Unpredictable results : A compromised dose might lead to fewer benefits or worse, side effectsif the active ingredient becomes unstable

C F Deacon [ Diabetes 1998;47(11):16631670] 53 FDA Approves New Treatment for Diabetes

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Disclosed by Mac Hadley, Robert Dorr, and colleagues at the University of Arizona in the 1980s as part of a systematic structure-activity programme, Melanotan II became one of the most-cited synthetic -MSH analogs in melanocortin research