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Seek immediate medical attention for these red-flag symptoms: Severe persistent abdominal pain, especially if radiating to the back (possible pancreatitis) Right upper quadrant pain with fever or jaundice (possible gallbladder disease) Severe constipation with abdominal distention or inability to pass gas (possible obstruction) Persistent vomiting or signs of dehydration Bloody or black stools Consider temporarily holding semaglutide during acute severe gastrointestinal illness or dehydration, in coordination with your prescribing physician