Who Is a Candidate for GLP-1/GIP Weight Loss Therapy
Monitoring High-Risk Patients For patients with risk factors like hypertension, diabetes, obesity, or a family history of heart disease, a baseline EKG provides a longitudinal tool for monitoring changes over time
GLP-1 medications are often used in patients with chronic kidney disease, and caution is warranted
13 The latest meta-analysis shows that AN adult patients have an average reduction of 0.16 kg in whole-body bone mineral content, 14 and there is no gender difference in the reduction of BMD in adolescent patients, 15 In terms of bone microstructure, abnormalities are observed in the distal radius and distal tibia of AN patients, manifested as reduced volumetric bone mineral density (vBMD), decreased cortical bone area and thickness, increased porosity, decreased trabecular bone density and increased separation degree, but the results of studies on trabecular bone number changes are inconsistent
Mullin TJ et al
The 8-(pyrrolidin-1-ylmethyl)4-trifluoromethyl ESC derivative exhibited a threefold longer half-life in human liver S9 fractions than the parent ESC, demonstrating the feasibility of improving pharmacokinetics through design (Choi et al