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26 In practice, prioritizing GLP-1 RAs in patients with type 2 diabetes and prominent obesity-related cardiometabolic risk is reasonable given the physiologic effects of these agents, whereas SGLT2 inhibitors may be favored when CKD or heart failure predominates
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Based on recent studies, SGLT2 inhibitors (SGLTis) are generally considered superior to GLP-1 receptor agonists (GLP-1s) for slowing the progression of chronic kidney disease
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GLP1(736) can directly suppress glucagon secretion in cells by increasing cAMP, activating PKA and EPAC, reducing intracellular calcium levels, and thereby decreasing glucagon release
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