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Yet, the evidence base is very limited, especially in humans

The reality is nuanced: the clinical significance of elevated B12 depends almost entirely on why its elevated

Its ability to reduce pro-inflammatory cytokines and improve microcirculation suggests a powerful role in easing joint pain, muscle fatigue, and connective tissue strain

FDA procedurally removed it from Category 2 in April 2026 after nominators withdrew their submissions and referred it to the Pharmacy Compounding Advisory Committee, which is scheduled to review it on July 23-24, 2026 for possible inclusion on the approved 503A bulks list

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HUBERMAN: Itself