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Investigators from The Salk Institute for Biological Studies published a paper in Proceedings of the National Academy of Sciences shedding some light on the mechanisms

Clinical, cosmetic and investigational dermatology , 267-274

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Notably, pharmacological blockade of opioid and benzodiazepine receptors partially reversed AST-mediated neuroprotection, suggesting that receptor-dependent mechanisms may contribute to its cognitive benefits beyond classical antioxidant activity (Rastinpour et al., 2025)

[9] If you do feel flush or itchy, it should be mild and short-lived

Before you begin, gather everything you'll need in one clean, quiet spot