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Once you reach the full dose at 9-16 weeks, it is typically a steady 1-3 pound of weight loss a week

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However, a high-fat diet and subsequent development of NASH can downregulate hepatic GLP-1R expression, thereby inducing therapeutic resistance to this medication in certain patients (Svegliati-Baroni et al., 2011

(7) Levothyroxine also interferes with blood glucose control, which can reduce the effectiveness of semaglutide in people using it to manage blood sugar

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