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Recently, LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results) study shows that GLP-1 analogue liraglutide treatment reduces the rates of cardiovascular events and death in patients with type 2 diabetes 9
PMID 3543057
Animal data indicates rapid clearance typical of unmodified small peptides, generally minutes to low hours in plasma
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PMC 4508243
The most common side effects listed in the prescribing information include gastrointestinal symptoms such as nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distension, eructation, flatulence, gastroenteritis, gastroesophageal reflux disease, and nasopharyngitis
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