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While this is an important limitation, these studies still provide valuable insights into how the peptide behaves biologically

HPLC-purified for high analytical purity, it is suitable for investigating peptide interactions and controlled experimental applications

The truth is more nuanced

In double-blind, placebo-controlled trials, daily application of GHK-Cu cream at 3% concentration for 12 weeks produced a 70% increase in skin collagen thickness as measured by ultrasound imaging, a 40% increase in skin elasticity, and visible reduction in fine lines and wrinkles

Research on ischemic and diabetic wound models has similarly reported meaningful improvements in wound closure rates alongside reduced inflammatory markers when GHK-Cu was introduced into the healing process

Additionally, our immunohistochemical (IHC) analysis revealed distinct expression patterns of mutant KRT32 of PRP patients compared to that in healthy controls and PRP patients without KRT32 mutations (Supplementary Fig