Excess visceral adiposity is strongly associated with: Type 2 diabetes mellitus and insulin resistance Cardiovascular disease and hypertension Non-alcoholic fatty liver disease (NAFLD) Certain cancers, including colorectal and breast cancer Metabolic syndrome According to NHS guidance, waist circumference measurements exceeding 94 cm in men and 80 cm in women (for white European populations) indicate increased metabolic risk, largely driven by visceral fat accumulation
However, combination therapy is not appropriate for everyone and requires medical evaluation and supervision
Recent evidence from the STEP-HFpEF and STEP-HFpEF-DM trials provides the first robust data supporting the efficacy of GLP-1 RAs, specifically semaglutide, in improving the quality of life in obese patients with HFpEF
While L-Carnitine is generally considered safe, some individuals may experience side effects such as nausea, abdominal cramps, or diarrhea
The fungal chitosan (an amino polysaccharide derived from Fusarium oxysporum ) loaded with bee venom nanoparticles was an effective anti-tumor agent for cervix carcinoma (HeLa cells) (211)
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