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Ventura C et al
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The studies demonstrated that long-term supplementation is responsible for an increase in blood glutathione levels (3)
For instance, pharmacokinetic vitamin-drug interaction studies have indicated a decreased uptake of the anticancer drug antifolate methotrexate in cancer cells, and the complexation of methotrexate and doxorubicin C into inactive adducts by riboflavin, thereby reducing the efficacy of these drugs 145
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