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The freed p53 then drives apoptosis selectively in senescent cells , while largely sparing healthy cells [1] [2]

Phase 2 trial (Lancet 2021) tested cagrilintide 0.3 mg through 4.5 mg/week as monotherapy and reported a clear dose-response, with 10.8% mean weight loss at 4.5 mg/week at 26 weeks

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