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Beyond 28 days, even refrigerated Melanotan-2 begins accumulating degradation products that reduce potency below acceptable thresholds
In the Phase 2 trial, participants on the 12mg dose of retatrutide lost up to 24.2% of their body weight over 48 weeks
Some patients may choose to lower their dose to see if they can maintain their weight at a reduced strength
PMID 38629387
Most patients notice real improvements in how they feel within three months
It is a once-weekly subcutaneous injection indicated in combination with a reduced-calorie diet and increased physical activity to reduce excess body weight and maintain weight reduction long term in adults with obesity or who are overweight
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