EAE experiments were terminated at the following stages of disease development: the onset stage is defined as the first time point at which immunized animals lose weight (710%) compared to the previous day, peak disease is defined as the first day the animals display a clinical score of 34 (with peak in scores), and recovery is defined as a distinct drop in score from a previous peak score of 34 to 12
Manufacturing capacity and supply scalability pose additional risks, especially during the early stages of commercialization
Avoid facilities lacking proper medical supervision or emergency equipment, as serious allergic reactions require immediate medical intervention
The supernatant was used for the analysis of LPO (Reference Ledwozyw, Michalak and Stepie25) , nitric oxide (NO) (Reference Miranda, Espey and Wink26) , GSH (Reference Beutler27) , glutathione-S-transferase (GST) (Reference Habig and Jakoby28) , SOD (Reference Mylroie, Collins and Umbles29) and tissue factor (TF) (Reference Ingram30) activities
Nitric oxide has fundamental vasodilator properties, reducing systemic vascular resistance and improving artery compliance, all of which would alleviate the haemodynamic burden in HF
rare with IV)
