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For example, GLP-1R-expressing vagal afferents have been shown to form intraganglionic laminar endings (IGLEs) mainly in the wall of the stomach/upper duodenum in mice [31, 32], such that they are selectively activated by gastric/duodenal stretch and CCK, but unexpectedly, not by exendin-4 [32]

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As a latecomer to this market with two well-established competitors that are far ahead, having this COGS advantage is key as it afford Pfizer more price flexibility in a cash-pay market

The BMJ study found that while GLP-1 drugs were linked to a slightly higher risk of hair loss, the overall risk remained low , and the benefits of these medicines generally outweigh this potential side effect