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Tesamorelin is a synthetic 44-amino-acid GHRH analog with a trans-3-hexenoic acid modification at the N-terminus and an extended plasma half-life, FDA-approved as Egrifta for visceral adipose tissue reduction in HIV-associated lipodystrophy

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A randomised controlled trial of exenatide (another GLP-1 receptor agonist) published in 2022 showed no overall benefit for alcohol use disorder compared to placebo, highlighting the need for caution in interpreting preliminary findings

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