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While a decrease in appetite is partially responsible for rapid weight loss, Semaglutide also changes the way in which the body processes hunger

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When protein intake is insufficient, the body may break down muscle tissue for energy, which can result in: Weakened muscles and reduced strength A slower metabolism, making calorie burning less efficient An increased risk of regaining weight after stopping the medication Additionally, research suggests that GLP-1 therapy decreases muscle protein synthesis, meaning the body has a harder time rebuilding lost muscle

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In female SE offspring, enhanced mitochondrial regeneration was suggested by decreased fission and increased fusion markers at day 1