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In the brain may reduce inflammation
Why dosing must be personalised and supervised Only a qualified prescriber will decide the correct/safe dose and schedule, based on medical history, other medicines, side effects and progress
Safe discontinuation requires healthcare provider assessment, potential alternative therapy, and increased glucose monitoring
All were registered via the "abbreviated development" (desenvolvimento abreviado) pathway, not the biosimilar comparability route
Similarly, sibutramine (Meridia), a serotonin and dopamine reuptake inhibitor that works by inducing satiety and increasing energy expenditure 8 , was approved in 1997 against a background of divided opinion on its safety profile because, while effective for weight-loss, it tended to increase blood pressure and pulse rate 6
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