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PMID 2306116

Additionally, the researchers speculated that BPC-157 may have induced the expression of EGR-1 and its repressor, nerve growth factor 1-A binding protein-2 (nab2), in non-differentiated Caco-2 cells more rapidly than PDGF-BB

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This suggests the cardiovascular system adapts over time

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Brain slice studies have shown that exendin-4 can increase the firing rates of DMH neurons, enhancing the neurons sensitivity to a high-fat diet (HFD) compared to a control diet [72]