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[131] [132] Species from the following genera and the following individual species are known to synthesize B 12 : Propionibacterium shermanii , Pseudomonas denitrificans , Streptomyces griseus , Acetobacterium , Aerobacter , Agrobacterium , Alcaligenes , Azotobacter , Bacillus , Clostridium , Corynebacterium , Flavobacterium , Lactobacillus , Micromonospora , Mycobacterium , Nocardia , Proteus , Rhizobium , Salmonella , Serratia , Streptococcus and Xanthomonas

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Additionally, B12 works closely with folate (vitamin B9) in DNA and RNA synthesis, essential for the growth and function of all cells in the body

In laboratory research, it has been examined for its potential interactions with nitric oxide signaling, vascular growth pathways, and cytoprotective mechanisms

Most of the early studies focused on its effects on the stomach and intestines