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Patients should contact their healthcare provider if gastrointestinal side effects do not improve after 68 weeks at a stable dose, as this may indicate poor tolerance requiring dose adjustment or medication discontinuation

Retatrutide is a novel triple-acting peptide agonist that simultaneously targets three key hormonal pathways: GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors

[3] Trappe SW, Costill DL, Goodpaster B, Vukovich MD, Fink WJ.Int J Sports Med

However, the combination of GLP-1 receptor agonists with DPP-4 inhibitors have not demonstrated clinically significant additional benefits [116]