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Equally impressive are the reported ramifications on the central and peripheral nervous systems

This is sometimes referred to as a methyl trap, where folate becomes functionally unavailable without sufficient B12, and vice versa

Possiblydepends on your medical profile

Homocysteine can be lowered by 1mg folic acid 500 mcg vitamin B12 and as little as 10 mg daily vitamin B6 over a 12-week period [9]