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The latest entrant, Zepbound, recently joined Ozempic, Wegovy, Victoza and others in a growing class of drugs called GLP-1 receptor agonists
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When used as a vector some of the proteins of the adenovirus are replaced by the gene for the antigen of the vaccine target
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Beneficial effects of GLP-1 in reducing toxic protein accumulation are hypothesized to occur through the PI3K/Akt inactivation of glycogen synthase kinase 3 beta (GSK3) [82] and a possible GLP-1 mediated upregulation of IDE [83]
10.4093/dmj.2019.0018 Diabetes Metab
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