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This oxidative damage activates signaling pathways that promote inflammation and fibrosis, leading to glomerular hypertrophy, mesangial expansion, and tubulointerstitial fibrosis [183]

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The Department has well-established procedures to deal with medicine shortages and works closely with all partners across the health system to help prevent shortages and ensure the risks to patients are minimised when they do arise. To help supply, the US Food and Drug Administration (FDA) has reduced the period of quarantine for plasma donations from 60 days to 45 days