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Semaglutide mimics glucagon-like peptide-1, a hormone your gut releases after eating
Constipation may occur when food intake drops, fluid intake decreases, fiber changes, movement declines, or digestion slows
Beas AO, Gordon PB, Prentiss CL, Olsen CP, Kukurugya MA, Bennett BD, et al
lying down immediately after meals can exacerbate digestive issues
For these patients, starting at 0.1 mg and titrating upward in smaller increments (0.1 to 0.15 to 0.2 to 0.25 mg) over 8 to 12 weeks may allow the GI tract to adapt without the abrupt disruption
10.1046/j.0306-5251.2001.01423.x 35 DawedA
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