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The study was registered at www.clinicaltrial.gov (Registration Number: NCT04766450)
In many cancer types, FAO is downregulated under hypoxia to reduce mitochondrial oxygen consumption and minimize ROS production, a strategy that aligns with the broader suppression of oxidative metabolism
1) Richie JP Jr, Leutzinger Y, Parthasarathy S, Malloy V, Orentreich N, Zimmerman JA
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L., & Horowitz, M
The resulting decrease in p62 leads to reduced sequestration of Keap1, thereby increasing Nrf2 stability and activating transcription of anti-ferroptosis genes [110]
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