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High consistency between the simulated profiles indicate that the PK in the phase 3 trials could be predicted using the two-compartment model that was developed using clinical pharmacology data, supporting the overall predictability of semaglutide PK

Other warnings issued with the use of semaglutide include the potential for pancreatitis, diabetic retinopathy complications, hypoglycemia, acute kidney injury, and hypersensitivity reactions

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Diabetes 68 (9), 17471755